High Content Screening

High Content Screening (HCS) workflows record images for multiple conditions at the same time, often in multi-well plates. The OME-TIFF specification provided first-class support for HCS, and the OME-Zarr addressed HCS needs early on, with a dedicated specification for plates and wells.

• The Fractal analytics framework for large scale processing with OME-Zarr has multiple workflows to analyse HCS data (preprint).

• Massei, R., Busch, W., Serrano-Solano, B. et al. High-content screening (HCS) workflows for FAIR image data management with OMERO. Sci Rep 15, 16236 (2025). https://doi.org/10.1038/s41598-025-00720-0