Volume EM#
Volume Electron Microscopy (vEM) includes a number of techniques for imaging large volumes of biological samples at high resolution. The OME-NGFF specification caters for this kind of big data nicely, and there are a number of resources that build upon OME-Zarr to provide additional support for vEM data.
Tools#
WebKnossos - A web-based platform for visualizing, annotating, and sharing large-scale volumetric datasets. It has native support for OME-Zarr and is widely used in the vEM community.
VolE - Allen Institute for Cell Science’s viewer for large-scale volumetric datasets, with native support for OME-Zarr.
Neuroglancer - Google’s WebGL-based viewer for volumetric data, with first class support for OME-Zarr.
SyGlass - A proprietary virtual reality platform for visualizing and analyzing large-scale volumetric datasets, with support for OME-Zarr.
Other#
WebKnossos Zarr Gallery- A gallery of OME-Zarr datasets, mostly vEM, hosted by WebKnossos.
CCP Volume EM OME-NGFF Hackathon, at EMBL-EBI, Hinxton, UK, March 2026
Chapter 14 - Toward scalable reuse of vEM data: OME-Zarr to the rescue - (paywalled) book chapter describing the value of OME-Zarr for volume EM data